Session Chair Profile

MBA, VP, BioPharma Business Development, Guardant Health, Inc.

Daniel is responsible for building Guardant’s partnerships with pharmaceutical and biotechnology companies using the Digital Sequencing technology platform. Daniel brings more than a decade of experience in the life sciences industry across business development, strategy, and operations. Previously, Daniel served in roles at MyoKardia, Onyx Pharmaceuticals, McKinsey & Company, and Genentech. He holds an MBA from the University of Pennsylvania’s Wharton School and an MA Hons. in Natural Sciences from the University of Cambridge.


Optimizing the Use of ctDNA to Accelerate Clinical Discoveries
Circulating cell-free tumor DNA (ctDNA) offers a non-invasive means to detect clinically actionable genomic alterations, and is an invaluable tool to identify the genomic basis of acquired resistance. This presentation will provide an overview of how ctDNA can be used to identify predictive biomarkers, monitor clonal evolution, and accelerate clinical discoveries. Examples from an ongoing clinical trial in patients with metastatic colorectal cancer will be presented.

Session Abstract

Session Synopsis: Comprehensive liquid biopsies are reducing trial timelines and costs. Identifying genomic alterations through a simple blood draw allows safer, faster and cheaper identification of patients for trials, as well as the rescue of those who fail tissue biopsy. The first liquid biopsy CDx are paving the way for broader clinical adoption. Longitudinal analysis of patient samples allows for monitoring of patient response and insights into tumor evolution and next-line therapy selection for patients, including oncology-immunotherapy.